Research Projects - current

Lay Abstract In the proposed EC study, we will (1) employ a randomized, double-blind, between-groups experimental design that will consist of 8 weeks of treatment with NAC (2400mg) or placebo medication; (2) use standardized, repeated dependent measures to rigorously assess AUD severity and PTSD symptomatology during treatment and follow-up; (3) collect biologic measures of alcohol use; (4) measure impairment in associated areas of functioning (e.g., depression, sleep, suicidality, family/social functioning); and (5) employ advanced neuroimaging techniques before and after treatment. This proposal is directly responsive to the mission of the Institute for Translational Neuroscience (ITN) and the U.S. Army/Department of Defense in that it seeks to accelerate the development of new, medication-based treatments to mitigate the impact of AUD and comorbid psychological conditions, such as PTSD, in the military/Veteran context.